Symbol: Name: ID: |
SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GFS:912 |
Gene name: | SLC29A1 |
Chromosome: | 6p21.1 |
Previous Symbols: | ENT1 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927073 | Rat Genome Database ID: | RGD:61899 |
HGNC ID: | HGNC:11003 | RefSeq IDs: | NM_001078174 |
Entrez Gene ID: | 2030 | Ensembl Gene ID: | ENSG00000112759 |
VEGA IDs: | OTTHUMG00000014759 | UniProt ID: | Q99808 |
UCSC ID: | uc003owy.1 | OMIM ID: | 602193 |
Pubmed: | PMID8986748 PMID 9344680 | ||
CCDS IDs: | CCDSCCDS4908.1 |
Equilibrative nucleoside transporter 1 (ENT1) is a protein that in humans is encoded by the SLC29A1 gene. This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq].
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Products for SLC29A1 gene
Catalog | Product Name | Application | Company |
GFS:E00912 | solute carrier family 29 (nucleoside transporters), member 1; ELISA kit | ELISA | n/a |
GFS:A00912 | solute carrier family 29 (nucleoside transporters), member 1; Anti | ANTIBODIES | n/a |
GFS:P00912 | solute carrier family 29 (nucleoside transporters), member 1; Protien | Protien | n/a |