Symbol: Name: ID: |
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 GFS:907 |
Gene name: | SLC27A5 |
Chromosome: | 19q13.43 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FATP5, VLACSR, VLCS-H2, VLCSH2, FACVL3, FLJ22987, ACSVL6, ACSB |
Name Aliases: | fatty-acid-Coenzyme A ligase, very long-chain 3 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347100 | Rat Genome Database ID: | RGD:708535 |
HGNC ID: | HGNC:10999 | RefSeq IDs: | NM_012254 |
Entrez Gene ID: | 10998 | Ensembl Gene ID: | ENSG00000083807 |
VEGA IDs: | UniProt ID: | Q9Y2P5 | |
UCSC ID: | uc002qtc.2 | OMIM ID: | 603314 |
Pubmed: | PMID10479480 PMID 10749848 | ||
CCDS IDs: | CCDSCCDS12983.1 |
Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene. The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq].
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Products for SLC27A5 gene
Catalog | Product Name | Application | Company |
GFS:E00907 | solute carrier family 27 (fatty acid transporter), member 5; ELISA kit | ELISA | n/a |
GFS:A00907 | solute carrier family 27 (fatty acid transporter), member 5; Anti | ANTIBODIES | n/a |
GFS:P00907 | solute carrier family 27 (fatty acid transporter), member 5; Protien | Protien | n/a |