Symbol: Name: ID: |
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 GFS:872 |
Gene name: | SLC22A2 |
Chromosome: | 6q25.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | 2-Oct |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1335072 | Rat Genome Database ID: | RGD:61936 |
HGNC ID: | HGNC:10966 | RefSeq IDs: | NM_003058 |
Entrez Gene ID: | 6582 | Ensembl Gene ID: | ENSG00000112499 |
VEGA IDs: | OTTHUMG00000015950 | UniProt ID: | O15244 |
UCSC ID: | uc003qtf.2 | OMIM ID: | 602608 |
Pubmed: | PMID9605850 | ||
CCDS IDs: | CCDSCCDS5276.1 |
Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
Products for SLC22A2 gene
Catalog | Product Name | Application | Company |
GFS:E00872 | solute carrier family 22 (organic cation transporter), member 2; ELISA kit | ELISA | n/a |
GFS:A00872 | solute carrier family 22 (organic cation transporter), member 2; Anti | ANTIBODIES | n/a |
GFS:P00872 | solute carrier family 22 (organic cation transporter), member 2; Protien | Protien | n/a |