Symbol: Name: ID: |
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 GFS:869 |
Gene name: | SLC22A1 |
Chromosome: | 6q25.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | 1-Oct |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108111 | Rat Genome Database ID: | RGD:3224 |
HGNC ID: | HGNC:10963 | RefSeq IDs: | NM_003057 |
Entrez Gene ID: | 6580 | Ensembl Gene ID: | ENSG00000175003 |
VEGA IDs: | OTTHUMG00000015947 | UniProt ID: | O15245 |
UCSC ID: | uc003qtc.2 | OMIM ID: | 602607 |
Pubmed: | PMID9605850 | ||
CCDS IDs: | CCDSCCDS5274.1 CCDS CCDS5275.1 |
Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq].
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium.
Products for SLC22A1 gene
Catalog | Product Name | Application | Company |
GFS:E00869 | solute carrier family 22 (organic cation transporter), member 1; ELISA kit | ELISA | n/a |
GFS:A00869 | solute carrier family 22 (organic cation transporter), member 1; Anti | ANTIBODIES | n/a |
GFS:P00869 | solute carrier family 22 (organic cation transporter), member 1; Protien | Protien | n/a |