Symbol: Name: ID: |
SLC18A2 solute carrier family 18 (vesicular monoamine), member 2 GFS:846 |
Gene name: | SLC18A2 |
Chromosome: | 10q25 |
Previous Symbols: | VMAT2 |
Previous Names: | |
Aliases: | SVMT, SVAT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106677 | Rat Genome Database ID: | RGD:3694 |
HGNC ID: | HGNC:10935 | RefSeq IDs: | NM_003054 |
Entrez Gene ID: | 6571 | Ensembl Gene ID: | ENSG00000165646 |
VEGA IDs: | OTTHUMG00000019121 | UniProt ID: | Q05940 |
UCSC ID: | uc001ldd.1 | OMIM ID: | 193001 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS7599.1 |
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
Products for SLC18A2 gene
Catalog | Product Name | Application | Company |
GFS:E00846 | solute carrier family 18 (vesicular monoamine), member 2; ELISA kit | ELISA | n/a |
GFS:A00846 | solute carrier family 18 (vesicular monoamine), member 2; Anti | ANTIBODIES | n/a |
GFS:P00846 | solute carrier family 18 (vesicular monoamine), member 2; Protien | Protien | n/a |