Symbol: Name: ID: |
SLC18A3 solute carrier family 18 (vesicular acetylcholine), member 3 GFS:847 |
Gene name: | SLC18A3 |
Chromosome: | 10q11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | VACHT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1101061 | Rat Genome Database ID: | RGD:62072 |
HGNC ID: | HGNC:10936 | RefSeq IDs: | NM_003055 |
Entrez Gene ID: | 6572 | Ensembl Gene ID: | ENSG00000187714 |
VEGA IDs: | OTTHUMG00000018196 | UniProt ID: | Q16572 |
UCSC ID: | uc001jhw.2 | OMIM ID: | 600336 |
Pubmed: | PMID8071310 | ||
CCDS IDs: | CCDSCCDS7231.1 |
SLC18A3 is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Vesicular acetylcholine transporters (VAChTs) are members of the solute carrier family 18 (SLC18) of ATP-dependent transporters that also includes vesicular monoamine transporters (VMAT) 1 and VMAT2. VAChT is found in the central and peripheral nervous systems in cholinergic pre-synaptic vesicle membranes of cholinergic neurons, where it is responsible for maintaining the concentration of acetylcholine (ACh). Cholinergic synaptic vesicles contain a H+-ATPase, which creates an electrical gradient across the vesicular membrane. VAChT acts as an ACh-H+ antiporter to facilitate the uptake of ACh. Interestingly, the VAChT gene is located within the first intron of the choline acetyltransferase gene (ChAT), the enzyme that catalyzes ACh synthesis from choline and acetyl coenzyme A. This may be to allow co-ordinated regulation of the two proteins.
Products for SLC18A3 gene
Catalog | Product Name | Application | Company |
GFS:E00847 | solute carrier family 18 (vesicular acetylcholine), member 3; ELISA kit | ELISA | n/a |
GFS:A00847 | solute carrier family 18 (vesicular acetylcholine), member 3; Anti | ANTIBODIES | n/a |
GFS:P00847 | solute carrier family 18 (vesicular acetylcholine), member 3; Protien | Protien | n/a |