Symbol: Name: ID: |
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 GFS:3294 |
Gene name: | SLC12A5 |
Chromosome: | 20q13.12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1176, KCC2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1862037 | Rat Genome Database ID: | RGD:620811 |
HGNC ID: | HGNC:13818 | RefSeq IDs: | NM_001134771 |
Entrez Gene ID: | 57468 | Ensembl Gene ID: | ENSG00000124140 |
VEGA IDs: | OTTHUMG00000032638 | UniProt ID: | Q9H2X9 |
UCSC ID: | uc010zxl.1 | OMIM ID: | 606726 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS13391.1 CCDS CCDS46610.1 |
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].
Function: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Products for SLC12A5 gene
Catalog | Product Name | Application | Company |
GFS:E03294 | solute carrier family 12 (potassium/chloride transporter), member 5; ELISA kit | ELISA | n/a |
GFS:A03294 | solute carrier family 12 (potassium/chloride transporter), member 5; Anti | ANTIBODIES | n/a |
GFS:P03294 | solute carrier family 12 (potassium/chloride transporter), member 5; Protien | Protien | n/a |