Symbol: Name: ID: |
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 GFS:850 |
Gene name: | SLC1A1 |
Chromosome: | 9p24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | EAAC1, EAAT3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105083 | Rat Genome Database ID: | RGD:3696 |
HGNC ID: | HGNC:10939 | RefSeq IDs: | NM_004170 |
Entrez Gene ID: | 6505 | Ensembl Gene ID: | ENSG00000106688 |
VEGA IDs: | OTTHUMG00000019468 | UniProt ID: | P43005 |
UCSC ID: | uc003zij.1 | OMIM ID: | 133550 |
Pubmed: | PMID8020993 | ||
CCDS IDs: | CCDSCCDS6452.1 |
Excitatory amino-acid transporter 3 is a protein that in humans is encoded by the SLC1A1 gene. This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq].
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and
potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.
Products for SLC1A1 gene
Catalog | Product Name | Application | Company |
GFS:E00850 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; ELISA kit | ELISA | n/a |
GFS:A00850 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Anti | ANTIBODIES | n/a |
GFS:P00850 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Protien | Protien | n/a |