Symbol: Name: ID: |
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 GFS:856 |
Gene name: | SLC1A6 |
Chromosome: | 19p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | EAAT4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1096331 | Rat Genome Database ID: | RGD:620340 |
HGNC ID: | HGNC:10944 | RefSeq IDs: | NM_005071 |
Entrez Gene ID: | 6511 | Ensembl Gene ID: | ENSG00000105143 |
VEGA IDs: | UniProt ID: | P48664 | |
UCSC ID: | uc002naa.1 | OMIM ID: | 600637 |
Pubmed: | PMID7791878 | ||
CCDS IDs: | CCDSCCDS12321.1 |
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and
potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.
Products for SLC1A6 gene
Catalog | Product Name | Application | Company |
GFS:E00856 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; ELISA kit | ELISA | n/a |
GFS:A00856 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; Anti | ANTIBODIES | n/a |
GFS:P00856 | solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; Protien | Protien | n/a |