Symbol: Name: ID: |
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 GFS:852 |
Gene name: | SLC1A2 |
Chromosome: | 11p13-p12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GLT-1, EAAT2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101931 | Rat Genome Database ID: | RGD:3697 |
HGNC ID: | HGNC:10940 | RefSeq IDs: | NM_001195728 |
Entrez Gene ID: | 6506 | Ensembl Gene ID: | ENSG00000110436 |
VEGA IDs: | OTTHUMG00000044391 | UniProt ID: | P43004 |
UCSC ID: | uc001mwd.2 | OMIM ID: | 600300 |
Pubmed: | PMID1448170 | ||
CCDS IDs: | CCDSCCDS31459.1 |
Excitatory amino-acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) is a protein that in humans is encoded by the SLC1A2 gene. This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq].
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.
Products for SLC1A2 gene
Catalog | Product Name | Application | Company |
GFS:E00852 | solute carrier family 1 (glial high affinity glutamate transporter), member 2; ELISA kit | ELISA | n/a |
GFS:A00852 | solute carrier family 1 (glial high affinity glutamate transporter), member 2; Anti | ANTIBODIES | n/a |
GFS:P00852 | solute carrier family 1 (glial high affinity glutamate transporter), member 2; Protien | Protien | n/a |