Symbol: Name: ID: |
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D GFS:5856 |
Gene name: | SEMA6D |
Chromosome: | 15q21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1479, FLJ11598 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2387661 | Rat Genome Database ID: | RGD:1310910 |
HGNC ID: | HGNC:16770 | RefSeq IDs: | NM_001198999 |
Entrez Gene ID: | 80031 | Ensembl Gene ID: | ENSG00000137872 |
VEGA IDs: | UniProt ID: | Q8NFY4 | |
UCSC ID: | uc001zvy.2 | OMIM ID: | 609295 |
Pubmed: | PMID12110693 PMID 14977921 | ||
CCDS IDs: | CCDSCCDS32224.1 CCDS CCDS32225.1 CCDS CCDS32226.1 CCDS CCDS32227.1 CCDS CCDS32228.1 CCDS CCDS32229.1 |
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010].
Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Products for SEMA6D gene
Catalog | Product Name | Application | Company |
GFS:E05856 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; ELISA kit | ELISA | n/a |
GFS:A05856 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Anti | ANTIBODIES | n/a |
GFS:P05856 | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Protien | Protien | n/a |