Symbol: Name: ID: |
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A GFS:642 |
Gene name: | SEMA3A |
Chromosome: | 7p12.1 |
Previous Symbols: | SEMAD |
Previous Names: | |
Aliases: | SEMA1, SemD, coll-1, Hsema-I |
Name Aliases: | sema III |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107558 | Rat Genome Database ID: | RGD:3657 |
HGNC ID: | HGNC:10723 | RefSeq IDs: | NM_006080 |
Entrez Gene ID: | 10371 | Ensembl Gene ID: | ENSG00000075213 |
VEGA IDs: | OTTHUMG00000023443 | UniProt ID: | Q14563 |
UCSC ID: | uc003uhz.2 | OMIM ID: | 603961 |
Pubmed: | PMID8269517 PMID 7748561 | ||
CCDS IDs: | CCDSCCDS5599.1 |
Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1 (By similarity)
Products for SEMA3A gene
Catalog | Product Name | Application | Company |
GFS:E00642 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; ELISA kit | ELISA | n/a |
GFS:A00642 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Anti | ANTIBODIES | n/a |
GFS:P00642 | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Protien | Protien | n/a |