Symbol: Name: ID: |
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A GFS:648 |
Gene name: | SEMA4A |
Chromosome: | 1q22 |
Previous Symbols: | SEMAB |
Previous Names: | |
Aliases: | SemB, FLJ12287 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107560 | Rat Genome Database ID: | RGD:1304636 |
HGNC ID: | HGNC:10729 | RefSeq IDs: | NM_001193300 |
Entrez Gene ID: | 64218 | Ensembl Gene ID: | ENSG00000196189 |
VEGA IDs: | OTTHUMG00000014042 | UniProt ID: | Q9H3S1 |
UCSC ID: | uc001fnm.2 | OMIM ID: | 607292 |
Pubmed: | PMID7748561 | ||
CCDS IDs: | CCDSCCDS1132.1 |
SEMA4A encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Products for SEMA4A gene
Catalog | Product Name | Application | Company |
GFS:E00648 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; ELISA kit | ELISA | n/a |
GFS:A00648 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; Anti | ANTIBODIES | n/a |
GFS:P00648 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; Protien | Protien | n/a |