Symbol: Name: ID: |
RUNX3 runt-related transcription factor 3 GFS:415 |
Gene name: | RUNX3 |
Chromosome: | 1p36 |
Previous Symbols: | CBFA3 |
Previous Names: | |
Aliases: | AML2, PEBP2A3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102672 | Rat Genome Database ID: | RGD:620082 |
HGNC ID: | HGNC:10473 | RefSeq IDs: | NM_001031680 |
Entrez Gene ID: | 864 | Ensembl Gene ID: | ENSG00000020633 |
VEGA IDs: | OTTHUMG00000003316 | UniProt ID: | Q13761 |
UCSC ID: | uc001bjq.2 | OMIM ID: | 600210 |
Pubmed: | PMID7835892 | ||
CCDS IDs: | CCDSCCDS257.1 CCDS CCDS30633.1 |
RUNX3 encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters
Products for RUNX3 gene
Catalog | Product Name | Application | Company |
GFS:E00415 | runt-related transcription factor 3; ELISA kit | ELISA | n/a |
GFS:A00415 | runt-related transcription factor 3; Anti | ANTIBODIES | n/a |
GFS:P00415 | runt-related transcription factor 3; Protien | Protien | n/a |