Symbol: Name: ID: |
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) GFS:4598 |
Gene name: | RUNX1T1 |
Chromosome: | 8q22 |
Previous Symbols: | AML1T1, CBFA2T1 |
Previous Names: | core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related |
Aliases: | CDR, ETO, MTG8, ZMYND2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104793 | Rat Genome Database ID: | RGD:1305490 |
HGNC ID: | HGNC:1535 | RefSeq IDs: | NM_001198625 |
Entrez Gene ID: | 862 | Ensembl Gene ID: | ENSG00000079102 |
VEGA IDs: | UniProt ID: | Q06455 | |
UCSC ID: | uc003yfd.2 | OMIM ID: | 133435 |
Pubmed: | PMID1391946 PMID 9790752 | ||
CCDS IDs: | CCDSCCDS6256.1 CCDS CCDS6257.1 CCDS CCDS47891.1 |
Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
Function: Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.
Products for RUNX1T1 gene
Catalog | Product Name | Application | Company |
GFS:E04598 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related); ELISA kit | ELISA | n/a |
GFS:A04598 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Anti | ANTIBODIES | n/a |
GFS:P04598 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Protien | Protien | n/a |