Symbol: Name: ID: |
RUNX2 runt-related transcription factor 2 GFS:414 |
Gene name: | RUNX2 |
Chromosome: | 6p21 |
Previous Symbols: | CCD, CBFA1, CCD1 |
Previous Names: | |
Aliases: | AML3, PEBP2A1, PEBP2aA1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99829 | Rat Genome Database ID: | RGD:2282 |
HGNC ID: | HGNC:10472 | RefSeq IDs: | NM_001015051 |
Entrez Gene ID: | 860 | Ensembl Gene ID: | ENSG00000124813 |
VEGA IDs: | OTTHUMG00000014774 | UniProt ID: | Q13950 |
UCSC ID: | uc011dvx.1 | OMIM ID: | 600211 |
Pubmed: | PMID7835892 | ||
CCDS IDs: | CCDSCCDS4913.1 CCDS CCDS43467.1 CCDS CCDS43468.1 |
RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq].
Products for RUNX2 gene
Catalog | Product Name | Application | Company |
GFS:E00414 | runt-related transcription factor 2; ELISA kit | ELISA | n/a |
GFS:A00414 | runt-related transcription factor 2; Anti | ANTIBODIES | n/a |
GFS:P00414 | runt-related transcription factor 2; Protien | Protien | n/a |