Symbol: Name: ID: |
RUNX1 runt-related transcription factor 1 GFS:413 |
Gene name: | RUNX1 |
Chromosome: | 21q22.3 |
Previous Symbols: | AML1, CBFA2 |
Previous Names: | acute myeloid leukemia 1 |
Aliases: | PEBP2A2, AMLCR1 |
Name Aliases: | aml1 oncogene |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99852 | Rat Genome Database ID: | RGD:2283 |
HGNC ID: | HGNC:10471 | RefSeq IDs: | NM_001001890 |
Entrez Gene ID: | 861 | Ensembl Gene ID: | ENSG00000159216 |
VEGA IDs: | OTTHUMG00000086299 | UniProt ID: | Q01196 |
UCSC ID: | uc010gmv.2 | OMIM ID: | 151385 |
Pubmed: | PMID1427868 PMID 7835892 | ||
CCDS IDs: | CCDSCCDS13639.1 CCDS CCDS42922.1 CCDS CCDS46646.1 |
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation
Products for RUNX1 gene
Catalog | Product Name | Application | Company |
GFS:E00413 | runt-related transcription factor 1; ELISA kit | ELISA | n/a |
GFS:A00413 | runt-related transcription factor 1; Anti | ANTIBODIES | n/a |
GFS:P00413 | runt-related transcription factor 1; Protien | Protien | n/a |