| Symbol: Name: ID: |
PADI4 peptidyl arginine deiminase, type IV GFS:7234 |
| Gene name: | PADI4 |
| Chromosome: | 1p36.13 |
| Previous Symbols: | PADI5 |
| Previous Names: | peptidyl arginine deiminase, type V |
| Aliases: | PAD, PDI5, PDI4 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1338898 | Rat Genome Database ID: | RGD:3290 |
| HGNC ID: | HGNC:18368 | RefSeq IDs: | NM_012387 |
| Entrez Gene ID: | 23569 | Ensembl Gene ID: | ENSG00000159339 |
| VEGA IDs: | OTTHUMG00000002371 | UniProt ID: | Q9UM07 |
| UCSC ID: | uc001baj.2 | OMIM ID: | 605347 |
| Pubmed: | PMID10488123 | ||
| CCDS IDs: | CCDSCCDS180.1 | ||
Peptidyl arginine deiminase, type IV, also known as PADI4, is a human protein which in humans is encoded by the PADI4 gene.
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008].
Function: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Products for PADI4 gene
| Catalog | Product Name | Application | Company |
| GFS:E07234 | peptidyl arginine deiminase, type IV; ELISA kit | ELISA | n/a |
| GFS:A07234 | peptidyl arginine deiminase, type IV; Anti | ANTIBODIES | n/a |
| GFS:P07234 | peptidyl arginine deiminase, type IV; Protien | Protien | n/a |
