Symbol: Name: ID: |
PADI2 peptidyl arginine deiminase, type II GFS:7212 |
Gene name: | PADI2 |
Chromosome: | 1p35.2-p35.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0994, PDI2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338892 | Rat Genome Database ID: | RGD:3288 |
HGNC ID: | HGNC:18341 | RefSeq IDs: | NM_007365 |
Entrez Gene ID: | 11240 | Ensembl Gene ID: | ENSG00000117115 |
VEGA IDs: | OTTHUMG00000002295 | UniProt ID: | Q9Y2J8 |
UCSC ID: | uc001baf.2 | OMIM ID: | 607935 |
Pubmed: | PMID2768262 | ||
CCDS IDs: | CCDSCCDS177.1 |
Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Catalyzes the deimination of arginine residues of proteins (By similarity).
Products for PADI2 gene
Catalog | Product Name | Application | Company |
GFS:E07212 | peptidyl arginine deiminase, type II; ELISA kit | ELISA | n/a |
GFS:A07212 | peptidyl arginine deiminase, type II; Anti | ANTIBODIES | n/a |
GFS:P07212 | peptidyl arginine deiminase, type II; Protien | Protien | n/a |