Symbol: Name: ID: |
PADI1 peptidyl arginine deiminase, type I GFS:7233 |
Gene name: | PADI1 |
Chromosome: | 1p36.13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HPAD10, PDI1, PDI, PAD1 |
Name Aliases: | peptidylarginine deiminase type I, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338893 | Rat Genome Database ID: | RGD:3287 |
HGNC ID: | HGNC:18367 | RefSeq IDs: | NM_013358 |
Entrez Gene ID: | 29943 | Ensembl Gene ID: | ENSG00000142623 |
VEGA IDs: | OTTHUMG00000002294 | UniProt ID: | Q9ULC6 |
UCSC ID: | uc001bah.1 | OMIM ID: | 607934 |
Pubmed: | PMID12416996 | ||
CCDS IDs: | CCDSCCDS178.1 |
Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Catalyzes the deimination of arginine residues of proteins (By similarity).
Products for PADI1 gene
Catalog | Product Name | Application | Company |
GFS:E07233 | peptidyl arginine deiminase, type I; ELISA kit | ELISA | n/a |
GFS:A07233 | peptidyl arginine deiminase, type I; Anti | ANTIBODIES | n/a |
GFS:P07233 | peptidyl arginine deiminase, type I; Protien | Protien | n/a |