Symbol: Name: ID: |
MYO1G myosin IG GFS:3340 |
Gene name: | MYO1G |
Chromosome: | 7p13-p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HA-2 |
Name Aliases: | minor histocompatibility antigen HA-2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927091 | Rat Genome Database ID: | RGD:1306016 |
HGNC ID: | HGNC:13880 | RefSeq IDs: | NM_033054 |
Entrez Gene ID: | 64005 | Ensembl Gene ID: | ENSG00000136286 |
VEGA IDs: | OTTHUMG00000155821 | UniProt ID: | B0I1T2 |
UCSC ID: | uc003tmh.2 | OMIM ID: | 613445 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS34629.1 |
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)
Function: Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201
Products for MYO1G gene
Catalog | Product Name | Application | Company |
GFS:E03340 | myosin IG; ELISA kit | ELISA | n/a |
GFS:A03340 | myosin IG; Anti | ANTIBODIES | n/a |
GFS:P03340 | myosin IG; Protien | Protien | n/a |