Symbol: Name: ID: |
MYOT myotilin GFS:2200 |
Gene name: | MYOT |
Chromosome: | 5q31.2 |
Previous Symbols: | TTID, LGMD1A, LGMD1 |
Previous Names: | titin immunoglobulin domain protein (myotilin), "limb-girdle muscular dystrophy 1A (autosomal dominant)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889800 | Rat Genome Database ID: | RGD:1310569 |
HGNC ID: | HGNC:12399 | RefSeq IDs: | NM_001135940 |
Entrez Gene ID: | 9499 | Ensembl Gene ID: | ENSG00000120729 |
VEGA IDs: | OTTHUMG00000129154 | UniProt ID: | Q9UBF9 |
UCSC ID: | uc003lbv.2 | OMIM ID: | 604103 |
Pubmed: | PMID10486214 PMID 10369880 | ||
CCDS IDs: | CCDSCCDS4194.1 CCDS CCDS47268.1 |
Myotilin is a protein that in humans is encoded by the MYOT gene. This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.
Products for MYOT gene
Catalog | Product Name | Application | Company |
GFS:E02200 | myotilin; ELISA kit | ELISA | n/a |
GFS:A02200 | myotilin; Anti | ANTIBODIES | n/a |
GFS:P02200 | myotilin; Protien | Protien | n/a |