Symbol: Name: ID: |
KDM5C lysine (K)-specific demethylase 5C GFS:1021 |
Gene name: | KDM5C |
Chromosome: | Xp11.22-p11.21 |
Previous Symbols: | SMCX, JARID1C |
Previous Names: | Jumonji, AT rich interactive domain 1C (RBP2-like), "Smcy homolog, X-linked (mouse)", "jumonji, AT rich interactive domain 1C" |
Aliases: | DXS1272E, XE169 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99781 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11114 | RefSeq IDs: | NM_001146702 |
Entrez Gene ID: | 8242 | Ensembl Gene ID: | ENSG00000126012 |
VEGA IDs: | OTTHUMG00000021606 | UniProt ID: | P41229 |
UCSC ID: | uc004drz.2 | OMIM ID: | 314690 |
Pubmed: | PMID7951230 PMID 8162017 | ||
CCDS IDs: | CCDSCCDS14351.1 |
Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
Products for KDM5C gene
Catalog | Product Name | Application | Company |
GFS:E01021 | lysine (K)-specific demethylase 5C; ELISA kit | ELISA | n/a |
GFS:A01021 | lysine (K)-specific demethylase 5C; Anti | ANTIBODIES | n/a |
GFS:P01021 | lysine (K)-specific demethylase 5C; Protien | Protien | n/a |