Symbol: Name: ID: |
KDM2A lysine (K)-specific demethylase 2A GFS:3150 |
Gene name: | KDM2A |
Chromosome: | 11q13.1 |
Previous Symbols: | FBXL11 |
Previous Names: | F-box and leucine-rich repeat protein 11 |
Aliases: | KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A |
Name Aliases: | F-box protein FBL11, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354736 | Rat Genome Database ID: | RGD:1309419 |
HGNC ID: | HGNC:13606 | RefSeq IDs: | NM_012308 |
Entrez Gene ID: | 22992 | Ensembl Gene ID: | ENSG00000173120 |
VEGA IDs: | UniProt ID: | Q9Y2K7 | |
UCSC ID: | uc001ojw.2 | OMIM ID: | 605657 |
Pubmed: | PMID10231032 PMID 10531037 | ||
CCDS IDs: | CCDSCCDS44657.1 |
Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in humans is encoded by the KDM2A gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
Function: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Products for KDM2A gene
Catalog | Product Name | Application | Company |
GFS:E03150 | lysine (K)-specific demethylase 2A; ELISA kit | ELISA | n/a |
GFS:A03150 | lysine (K)-specific demethylase 2A; Anti | ANTIBODIES | n/a |
GFS:P03150 | lysine (K)-specific demethylase 2A; Protien | Protien | n/a |