Symbol: Name: ID: |
KDM2B lysine (K)-specific demethylase 2B GFS:3155 |
Gene name: | KDM2B |
Chromosome: | 12q24.31 |
Previous Symbols: | FBXL10 |
Previous Names: | F-box and leucine-rich repeat protein 10 |
Aliases: | PCCX2, CXXC2, Fbl10, JHDM1B |
Name Aliases: | jumonji C domain-containing histone demethylase 1B |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354737 | Rat Genome Database ID: | RGD:1310217 |
HGNC ID: | HGNC:13610 | RefSeq IDs: | NM_001005366 |
Entrez Gene ID: | 84678 | Ensembl Gene ID: | ENSG00000089094 |
VEGA IDs: | UniProt ID: | Q8NHM5 | |
UCSC ID: | uc001uat.2 | OMIM ID: | 609078 |
Pubmed: | PMID10799292 | ||
CCDS IDs: | CCDSCCDS41849.1 CCDS CCDS41850.1 |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Products for KDM2B gene
Catalog | Product Name | Application | Company |
GFS:E03155 | lysine (K)-specific demethylase 2B; ELISA kit | ELISA | n/a |
GFS:A03155 | lysine (K)-specific demethylase 2B; Anti | ANTIBODIES | n/a |
GFS:P03155 | lysine (K)-specific demethylase 2B; Protien | Protien | n/a |