| Symbol: Name: ID: |
KDM5B lysine (K)-specific demethylase 5B GFS:6930 |
| Gene name: | KDM5B |
| Chromosome: | 1q32.1 |
| Previous Symbols: | JARID1B |
| Previous Names: | Jumonji, AT rich interactive domain 1B (RBP2-like), "jumonji, AT rich interactive domain 1B" |
| Aliases: | RBBP2H1A, PLU-1, CT31 |
| Name Aliases: | cancer/testis antigen 31 |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1922855 | Rat Genome Database ID: | RGD:1565602 |
| HGNC ID: | HGNC:18039 | RefSeq IDs: | NM_006618 |
| Entrez Gene ID: | 10765 | Ensembl Gene ID: | ENSG00000117139 |
| VEGA IDs: | OTTHUMG00000041401 | UniProt ID: | Q9UGL1 |
| UCSC ID: | uc001gyf.2 | OMIM ID: | 605393 |
| Pubmed: | PMID11483573 PMID 11478881 | ||
| CCDS IDs: | CCDSCCDS30974.1 | ||
Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.
Function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Products for KDM5B gene
| Catalog | Product Name | Application | Company |
| GFS:E06930 | lysine (K)-specific demethylase 5B; ELISA kit | ELISA | n/a |
| GFS:A06930 | lysine (K)-specific demethylase 5B; Anti | ANTIBODIES | n/a |
| GFS:P06930 | lysine (K)-specific demethylase 5B; Protien | Protien | n/a |
