Symbol: Name: ID: |
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 GFS:5433 |
Gene name: | KIR3DL3 |
Chromosome: | 19q13.4 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIRC1, KIR3DL7, KIR44, CD158z |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3612791 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16312 | RefSeq IDs: | NM_153443 |
Entrez Gene ID: | 115653 | Ensembl Gene ID: | ENSG00000242019 |
VEGA IDs: | OTTHUMG00000065884 | UniProt ID: | Q8N743 |
UCSC ID: | uc002qgu.1 | OMIM ID: | 610095 |
Pubmed: | PMID11513144 | ||
CCDS IDs: | CCDSCCDS12903.1 |
Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
Products for KIR3DL3 gene
Catalog | Product Name | Application | Company |
GFS:E05433 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3; ELISA kit | ELISA | n/a |
GFS:A05433 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3; Anti | ANTIBODIES | n/a |
GFS:P05433 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3; Protien | Protien | n/a |