Symbol: Name: ID: |
KIRREL kin of IRRE like (Drosophila) GFS:4891 |
Gene name: | KIRREL |
Chromosome: | 1q21-q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NEPH1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891396 | Rat Genome Database ID: | RGD:727883 |
HGNC ID: | HGNC:15734 | RefSeq IDs: | NM_018240 |
Entrez Gene ID: | 55243 | Ensembl Gene ID: | ENSG00000183853 |
VEGA IDs: | OTTHUMG00000022438 | UniProt ID: | Q96J84 |
UCSC ID: | uc001frn.3 | OMIM ID: | 607428 |
Pubmed: | PMID12424224 | ||
CCDS IDs: | CCDSCCDS1172.2 |
Kin of IRRE-like protein 1 is a protein that in humans is encoded by the KIRREL gene.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Products for KIRREL gene
Catalog | Product Name | Application | Company |
GFS:E04891 | kin of IRRE like (Drosophila); ELISA kit | ELISA | n/a |
GFS:A04891 | kin of IRRE like (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P04891 | kin of IRRE like (Drosophila); Protien | Protien | n/a |