Symbol: Name: ID: |
XPO7 exportin 7 GFS:3525 |
Gene name: | XPO7 |
Chromosome: | 8p21 |
Previous Symbols: | RANBP16 |
Previous Names: | RAN binding protein 16 |
Aliases: | KIAA0745 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929705 | Rat Genome Database ID: | RGD:1310928 |
HGNC ID: | HGNC:14108 | RefSeq IDs: | NM_015024 |
Entrez Gene ID: | 23039 | Ensembl Gene ID: | ENSG00000130227 |
VEGA IDs: | UniProt ID: | Q9UIA9 | |
UCSC ID: | uc010lti.2 | OMIM ID: | 606140 |
Pubmed: | PMID11024021 PMID 9872452 | ||
CCDS IDs: | CCDSCCDS47818.1 |
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.(supplied by OMIM) .
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Products for XPO7 gene
Catalog | Product Name | Application | Company |
GFS:E03525 | exportin 7; ELISA kit | ELISA | n/a |
GFS:A03525 | exportin 7; Anti | ANTIBODIES | n/a |
GFS:P03525 | exportin 7; Protien | Protien | n/a |