Symbol: Name: ID: |
XPO5 exportin 5 GFS:6615 |
Gene name: | XPO5 |
Chromosome: | 6p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1291 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913789 | Rat Genome Database ID: | RGD:1311522 |
HGNC ID: | HGNC:17675 | RefSeq IDs: | NM_020750 |
Entrez Gene ID: | 57510 | Ensembl Gene ID: | ENSG00000124571 |
VEGA IDs: | OTTHUMG00000014742 | UniProt ID: | Q9HAV4 |
UCSC ID: | uc003ovp.2 | OMIM ID: | 607845 |
Pubmed: | PMID11777942 PMID 12426392 | ||
CCDS IDs: | CCDSCCDS47430.1 |
Exportin-5 is a protein that in humans is encoded by the XPO5 gene.
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi)
Function: Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.
Products for XPO5 gene
Catalog | Product Name | Application | Company |
GFS:E06615 | exportin 5; ELISA kit | ELISA | n/a |
GFS:A06615 | exportin 5; Anti | ANTIBODIES | n/a |
GFS:P06615 | exportin 5; Protien | Protien | n/a |