Symbol: Name: ID: |
XPOT exportin, tRNA (nuclear export receptor for tRNAs) GFS:2577 |
Gene name: | XPOT |
Chromosome: | 12q14.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | XPO3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920442 | Rat Genome Database ID: | RGD:1305562 |
HGNC ID: | HGNC:12826 | RefSeq IDs: | NM_007235 |
Entrez Gene ID: | 11260 | Ensembl Gene ID: | ENSG00000184575 |
VEGA IDs: | UniProt ID: | O43592 | |
UCSC ID: | uc001ssb.2 | OMIM ID: | 603180 |
Pubmed: | PMID9660920 PMID 9512417 | ||
CCDS IDs: | CCDSCCDS31852.1 |
Exportin-T is a protein that in humans is encoded by the XPOT gene.
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq].
Function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Products for XPOT gene
Catalog | Product Name | Application | Company |
GFS:E02577 | exportin, tRNA (nuclear export receptor for tRNAs); ELISA kit | ELISA | n/a |
GFS:A02577 | exportin, tRNA (nuclear export receptor for tRNAs); Anti | ANTIBODIES | n/a |
GFS:P02577 | exportin, tRNA (nuclear export receptor for tRNAs); Protien | Protien | n/a |