Symbol: Name: ID: |
XPO4 exportin 4 GFS:6700 |
Gene name: | XPO4 |
Chromosome: | 13q11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ13046, KIAA1721 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888526 | Rat Genome Database ID: | RGD:1312015 |
HGNC ID: | HGNC:17796 | RefSeq IDs: | NM_022459 |
Entrez Gene ID: | 64328 | Ensembl Gene ID: | ENSG00000132953 |
VEGA IDs: | OTTHUMG00000016528 | UniProt ID: | Q9C0E2 |
UCSC ID: | uc001unq.3 | OMIM ID: | 611449 |
Pubmed: | PMID11214970 PMID 10944119 | ||
CCDS IDs: | CCDSCCDS41872.1 |
Exportin-4 is a protein that in humans is encoded by the XPO4 gene.
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Products for XPO4 gene
Catalog | Product Name | Application | Company |
GFS:E06700 | exportin 4; ELISA kit | ELISA | n/a |
GFS:A06700 | exportin 4; Anti | ANTIBODIES | n/a |
GFS:P06700 | exportin 4; Protien | Protien | n/a |