Symbol: Name: ID: |
CFL2 cofilin 2 (muscle) GFS:7585 |
Gene name: | CFL2 |
Chromosome: | 14q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101763 | Rat Genome Database ID: | RGD:1306982 |
HGNC ID: | HGNC:1875 | RefSeq IDs: | NM_021914 |
Entrez Gene ID: | 1073 | Ensembl Gene ID: | ENSG00000165410 |
VEGA IDs: | OTTHUMG00000029536 | UniProt ID: | Q9Y281 |
UCSC ID: | uc001wsh.3 | OMIM ID: | 601443 |
Pubmed: | PMID8800436 | ||
CCDS IDs: | CCDSCCDS9649.1 CCDS CCDS9650.1 |
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].
Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
Products for CFL2 gene
Catalog | Product Name | Application | Company |
GFS:E07585 | cofilin 2 (muscle); ELISA kit | ELISA | n/a |
GFS:A07585 | cofilin 2 (muscle); Anti | ANTIBODIES | n/a |
GFS:P07585 | cofilin 2 (muscle); Protien | Protien | n/a |