Symbol: Name: ID: |
CFL1 cofilin 1 (non-muscle) GFS:7574 |
Gene name: | CFL1 |
Chromosome: | 11q13.1 |
Previous Symbols: | CFL |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101757 | Rat Genome Database ID: | RGD:69285 |
HGNC ID: | HGNC:1874 | RefSeq IDs: | NM_005507 |
Entrez Gene ID: | 1072 | Ensembl Gene ID: | ENSG00000172757 |
VEGA IDs: | UniProt ID: | P23528 | |
UCSC ID: | uc001ofs.2 | OMIM ID: | 601442 |
Pubmed: | PMID8800436 | ||
CCDS IDs: | CCDSCCDS8114.1 |
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Products for CFL1 gene
Catalog | Product Name | Application | Company |
GFS:E07574 | cofilin 1 (non-muscle); ELISA kit | ELISA | n/a |
GFS:A07574 | cofilin 1 (non-muscle); Anti | ANTIBODIES | n/a |
GFS:P07574 | cofilin 1 (non-muscle); Protien | Protien | n/a |