Symbol: Name: ID: |
CFLAR CASP8 and FADD-like apoptosis regulator GFS:7595 |
Gene name: | CFLAR |
Chromosome: | 2q33-q34 |
Previous Symbols: | CASP8AP1 |
Previous Names: | |
Aliases: | CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT, c-FLIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1336166 | Rat Genome Database ID: | RGD:620847 |
HGNC ID: | HGNC:1876 | RefSeq IDs: | NM_001127183 |
Entrez Gene ID: | 8837 | Ensembl Gene ID: | ENSG00000003402 |
VEGA IDs: | OTTHUMG00000132819 | UniProt ID: | O15519 |
UCSC ID: | uc002uxb.3 | OMIM ID: | 603599 |
Pubmed: | PMID9208847 PMID 9217161 | ||
CCDS IDs: | CCDSCCDS2337.1 CCDS CCDS46487.1 |
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called FLICE-like inhibitory protein (FLIP).
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Products for CFLAR gene
Catalog | Product Name | Application | Company |
GFS:E07595 | CASP8 and FADD-like apoptosis regulator; ELISA kit | ELISA | n/a |
GFS:A07595 | CASP8 and FADD-like apoptosis regulator; Anti | ANTIBODIES | n/a |
GFS:P07595 | CASP8 and FADD-like apoptosis regulator; Protien | Protien | n/a |