Symbol: Name: ID: |
CBX5 chromobox homolog 5 GFS:4749 |
Gene name: | CBX5 |
Chromosome: | 12q13.13 |
Previous Symbols: | |
Previous Names: | chromobox homolog 5 (Drosophila HP1 alpha), "chromobox homolog 5 (HP1 alpha homolog, Drosophila)" |
Aliases: | HP1Hs-alpha, HP1, HP1-ALPHA |
Name Aliases: | HP1 alpha homolog (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109372 | Rat Genome Database ID: | RGD:1306619 |
HGNC ID: | HGNC:1555 | RefSeq IDs: | NM_001127321 |
Entrez Gene ID: | 23468 | Ensembl Gene ID: | ENSG00000094916 |
VEGA IDs: | UniProt ID: | P45973 | |
UCSC ID: | uc001sfj.3 | OMIM ID: | 604478 |
Pubmed: | PMID8663349 | ||
CCDS IDs: | CCDSCCDS8875.1 |
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Products for CBX5 gene
Catalog | Product Name | Application | Company |
GFS:E04749 | chromobox homolog 5; ELISA kit | ELISA | n/a |
GFS:A04749 | chromobox homolog 5; Anti | ANTIBODIES | n/a |
GFS:P04749 | chromobox homolog 5; Protien | Protien | n/a |