Symbol: Name: ID: |
CBX1 chromobox homolog 1 GFS:4715 |
Gene name: | CBX1 |
Chromosome: | 17q21.32 |
Previous Symbols: | |
Previous Names: | chromobox homolog 1 (Drosophila HP1 beta) |
Aliases: | HP1Hs-beta, M31, MOD1, CBX, HP1-BETA |
Name Aliases: | HP1 beta homolog (Drosophila ) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105369 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1551 | RefSeq IDs: | NM_001127228 |
Entrez Gene ID: | 10951 | Ensembl Gene ID: | ENSG00000108468 |
VEGA IDs: | OTTHUMG00000150417 | UniProt ID: | P83916 |
UCSC ID: | uc002ind.3 | OMIM ID: | 604511 |
Pubmed: | PMID9169582 | ||
CCDS IDs: | CCDSCCDS11525.1 |
Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Function: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Products for CBX1 gene
Catalog | Product Name | Application | Company |
GFS:E04715 | chromobox homolog 1; ELISA kit | ELISA | n/a |
GFS:A04715 | chromobox homolog 1; Anti | ANTIBODIES | n/a |
GFS:P04715 | chromobox homolog 1; Protien | Protien | n/a |