Symbol: Name: ID: |
CBX2 chromobox homolog 2 GFS:4726 |
Gene name: | CBX2 |
Chromosome: | 17q25.3 |
Previous Symbols: | CDCA6 |
Previous Names: | chromobox homolog 2 (Drosophila Pc class), "cell division cycle associated 6" |
Aliases: | MGC10561 |
Name Aliases: | Pc class homolog (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88289 | Rat Genome Database ID: | RGD:1588561 |
HGNC ID: | HGNC:1552 | RefSeq IDs: | NM_005189 |
Entrez Gene ID: | 84733 | Ensembl Gene ID: | ENSG00000173894 |
VEGA IDs: | OTTHUMG00000141729 | UniProt ID: | Q14781 |
UCSC ID: | uc002jxc.2 | OMIM ID: | 602770 |
Pubmed: | PMID7782071 PMID 2477932 | ||
CCDS IDs: | CCDSCCDS11764.1 CCDS CCDS32757.1 |
Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene. According to a New Scientist CBX2 controls human gender even more so than X/Y chromosomes.
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010].
Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Products for CBX2 gene
Catalog | Product Name | Application | Company |
GFS:E04726 | chromobox homolog 2; ELISA kit | ELISA | n/a |
GFS:A04726 | chromobox homolog 2; Anti | ANTIBODIES | n/a |
GFS:P04726 | chromobox homolog 2; Protien | Protien | n/a |