Symbol: Name: ID: |
CBX3 chromobox homolog 3 GFS:4736 |
Gene name: | CBX3 |
Chromosome: | 7p15.2 |
Previous Symbols: | |
Previous Names: | chromobox homolog 3 (Drosophila HP1 gamma) |
Aliases: | HP1Hs-gamma |
Name Aliases: | HP1 gamma homolog (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108515 | Rat Genome Database ID: | RGD:1549705 |
HGNC ID: | HGNC:1553 | RefSeq IDs: | NM_007276 |
Entrez Gene ID: | 11335 | Ensembl Gene ID: | ENSG00000122565 |
VEGA IDs: | OTTHUMG00000022911 | UniProt ID: | Q13185 |
UCSC ID: | uc003sxt.2 | OMIM ID: | 604477 |
Pubmed: | PMID8663349 | ||
CCDS IDs: | CCDSCCDS5398.1 |
Chromobox protein homolog 3 is a protein that in humans is encoded by the CBX3 gene.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011].
Function: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Products for CBX3 gene
Catalog | Product Name | Application | Company |
GFS:E04736 | chromobox homolog 3; ELISA kit | ELISA | n/a |
GFS:A04736 | chromobox homolog 3; Anti | ANTIBODIES | n/a |
GFS:P04736 | chromobox homolog 3; Protien | Protien | n/a |