Symbol: Name: ID: |
BMP4 bone morphogenetic protein 4 GFS:627 |
Gene name: | BMP4 |
Chromosome: | 14q22-q23 |
Previous Symbols: | BMP2B |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88180 | Rat Genome Database ID: | RGD:2213 |
HGNC ID: | HGNC:1071 | RefSeq IDs: | NM_001202 |
Entrez Gene ID: | 652 | Ensembl Gene ID: | ENSG00000125378 |
VEGA IDs: | OTTHUMG00000140303 | UniProt ID: | P12644 |
UCSC ID: | uc010aoh.2 | OMIM ID: | 112262 |
Pubmed: | PMID7558046 PMID 7579580 | ||
CCDS IDs: | CCDSCCDS9715.1 |
Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene.The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq].
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)
Products for BMP4 gene
Catalog | Product Name | Application | Company |
GFS:E00627 | bone morphogenetic protein 4; ELISA kit | ELISA | n/a |
GFS:A00627 | bone morphogenetic protein 4; Anti | ANTIBODIES | n/a |
GFS:P00627 | bone morphogenetic protein 4; Protien | Protien | n/a |