Symbol: Name: ID: |
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) GFS:698 |
Gene name: | BMPR2 |
Chromosome: | 2q33-q34 |
Previous Symbols: | PPH1 |
Previous Names: | primary pulmonary hypertension 1 |
Aliases: | BRK-3, T-ALK, BMPR3, BMPR-II |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1095407 | Rat Genome Database ID: | RGD:71082 |
HGNC ID: | HGNC:1078 | RefSeq IDs: | NM_001204 |
Entrez Gene ID: | 659 | Ensembl Gene ID: | ENSG00000204217 |
VEGA IDs: | OTTHUMG00000133617 | UniProt ID: | Q13873 |
UCSC ID: | uc002uzf.3 | OMIM ID: | 600799 |
Pubmed: | PMID7791754 | ||
CCDS IDs: | CCDSCCDS33361.1 |
BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for BMPR2 gene
Catalog | Product Name | Application | Company |
GFS:E00698 | bone morphogenetic protein receptor, type II (serine/threonine kinase); ELISA kit | ELISA | n/a |
GFS:A00698 | bone morphogenetic protein receptor, type II (serine/threonine kinase); Anti | ANTIBODIES | n/a |
GFS:P00698 | bone morphogenetic protein receptor, type II (serine/threonine kinase); Protien | Protien | n/a |