Symbol: Name: ID: |
BMPR1A bone morphogenetic protein receptor, type IA GFS:678 |
Gene name: | BMPR1A |
Chromosome: | 10q22.3 |
Previous Symbols: | ACVRLK3 |
Previous Names: | |
Aliases: | ALK3, CD292 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338938 | Rat Genome Database ID: | RGD:70989 |
HGNC ID: | HGNC:1076 | RefSeq IDs: | NM_004329 |
Entrez Gene ID: | 657 | Ensembl Gene ID: | ENSG00000107779 |
VEGA IDs: | OTTHUMG00000018657 | UniProt ID: | P36894 |
UCSC ID: | uc001kdy.2 | OMIM ID: | 601299 |
Pubmed: | PMID8397373 PMID 9730621 | ||
CCDS IDs: | CCDSCCDS7378.1 |
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4
Products for BMPR1A gene
Catalog | Product Name | Application | Company |
GFS:E00678 | bone morphogenetic protein receptor, type IA; ELISA kit | ELISA | n/a |
GFS:A00678 | bone morphogenetic protein receptor, type IA; Anti | ANTIBODIES | n/a |
GFS:P00678 | bone morphogenetic protein receptor, type IA; Protien | Protien | n/a |