Symbol: Name: ID: |
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G GFS:6435 |
Gene name: | APOBEC3G |
Chromosome: | 22q13.1-q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CEM15, MDS019, dJ494G10.1, FLJ12740, bK150C2.7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:17357 | RefSeq IDs: | NM_021822 |
Entrez Gene ID: | 60489 | Ensembl Gene ID: | ENSG00000239713 |
VEGA IDs: | OTTHUMG00000151081 | UniProt ID: | Q9HC16 |
UCSC ID: | uc003awx.2 | OMIM ID: | 607113 |
Pubmed: | PMID11863358 | ||
CCDS IDs: | CCDSCCDS13984.1 |
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. APOBEC3G binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.
Products for APOBEC3G gene
Catalog | Product Name | Application | Company |
GFS:E06435 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; ELISA kit | ELISA | n/a |
GFS:A06435 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; Anti | ANTIBODIES | n/a |
GFS:P06435 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; Protien | Protien | n/a |