Symbol: Name: ID: |
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A GFS:6421 |
Gene name: | APOBEC3A |
Chromosome: | 22q13.1-q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ARP3, PHRBN |
Name Aliases: | phorbolin I |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:17343 | RefSeq IDs: | XM_003118814 |
Entrez Gene ID: | 200315 | Ensembl Gene ID: | ENSG00000128383 |
VEGA IDs: | OTTHUMG00000151004 | UniProt ID: | P31941 |
UCSC ID: | OMIM ID: | 607109 | |
Pubmed: | PMID11863358 PMID 10469298 | ||
CCDS IDs: | CCDSCCDS13981.1 |
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, is a gene of the APOBEC3 family found in at least in humans.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. (provided by RefSeq)
Function: Lacks cytidine deaminase activity, at least on RNA molecules (monomeric nucleoside substrates or synthetic apoB RNA template). Unable to reduce HIV-1 infectivity in vitro.
Products for APOBEC3A gene
Catalog | Product Name | Application | Company |
GFS:E06421 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ELISA kit | ELISA | n/a |
GFS:A06421 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; Anti | ANTIBODIES | n/a |
GFS:P06421 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; Protien | Protien | n/a |