Symbol: Name: ID: |
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F GFS:6434 |
Gene name: | APOBEC3F |
Chromosome: | 22q13.1-q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ARP8, BK150C2.4.MRNA, KA6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:17356 | RefSeq IDs: | NM_001006666 |
Entrez Gene ID: | 200316 | Ensembl Gene ID: | ENSG00000128394 |
VEGA IDs: | OTTHUMG00000151080 | UniProt ID: | Q8IUX4 |
UCSC ID: | uc003aww.2 | OMIM ID: | 608993 |
Pubmed: | PMID11863358 PMID 17121840 | ||
CCDS IDs: | CCDSCCDS33648.1 CCDS CCDS33649.1 |
DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: After being packaged into HIV-1 virions, blocks productive infection by massively editing dC residues to dU on the DNA minus strand during reverse transcription. The editing of the minus strand DNA of HIV-1 during reverse transcription leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations.
Products for APOBEC3F gene
Catalog | Product Name | Application | Company |
GFS:E06434 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; ELISA kit | ELISA | n/a |
GFS:A06434 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; Anti | ANTIBODIES | n/a |
GFS:P06434 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; Protien | Protien | n/a |