Symbol: Name: ID: |
ASB2 ankyrin repeat and SOCS box containing 2 GFS:5142 |
Gene name: | ASB2 |
Chromosome: | 14q31-q32 |
Previous Symbols: | |
Previous Names: | ankyrin repeat and SOCS box-containing 2 |
Aliases: | ASB-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929743 | Rat Genome Database ID: | RGD:1306414 |
HGNC ID: | HGNC:16012 | RefSeq IDs: | NM_001202429 |
Entrez Gene ID: | 51676 | Ensembl Gene ID: | ENSG00000100628 |
VEGA IDs: | UniProt ID: | Q96Q27 | |
UCSC ID: | uc001ycc.1 | OMIM ID: | 605759 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS9915.1 |
Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Products for ASB2 gene
Catalog | Product Name | Application | Company |
GFS:E05142 | ankyrin repeat and SOCS box containing 2; ELISA kit | ELISA | n/a |
GFS:A05142 | ankyrin repeat and SOCS box containing 2; Anti | ANTIBODIES | n/a |
GFS:P05142 | ankyrin repeat and SOCS box containing 2; Protien | Protien | n/a |