Symbol: Name: ID: |
ACOT8 acyl-CoA thioesterase 8 GFS:5050 |
Gene name: | ACOT8 |
Chromosome: | 20pter-p12.3 |
Previous Symbols: | PTE1 |
Previous Names: | peroxisomal acyl-CoA thioesterase, "peroxisomal acyl-CoA thioesterase 1" |
Aliases: | hACTE-III, hTE, PTE-2 |
Name Aliases: | choloyl-CoA hydrolase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2158201 | Rat Genome Database ID: | RGD:70368 |
HGNC ID: | HGNC:15919 | RefSeq IDs: | NM_005469 |
Entrez Gene ID: | 10005 | Ensembl Gene ID: | ENSG00000101473 |
VEGA IDs: | OTTHUMG00000033045 | UniProt ID: | O14734 |
UCSC ID: | uc002xqa.1 | OMIM ID: | 608123 |
Pubmed: | PMID10092594 PMID 9153233 PMID 16103133 PMID 16940157 | ||
CCDS IDs: | CCDSCCDS13378.1 |
Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.
Products for ACOT8 gene
Catalog | Product Name | Application | Company |
GFS:E05050 | acyl-CoA thioesterase 8; ELISA kit | ELISA | n/a |
GFS:A05050 | acyl-CoA thioesterase 8; Anti | ANTIBODIES | n/a |
GFS:P05050 | acyl-CoA thioesterase 8; Protien | Protien | n/a |