Symbol: Name: ID: |
ACVR2B activin A receptor, type IIB GFS:6469 |
Gene name: | ACVR2B |
Chromosome: | 3p22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ActR-IIB |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:87912 | Rat Genome Database ID: | RGD:2028 |
HGNC ID: | HGNC:174 | RefSeq IDs: | NM_001106 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000114739 | |
VEGA IDs: | OTTHUMG00000131291 | UniProt ID: | Q13705 |
UCSC ID: | uc003cif.2 | OMIM ID: | 602730 |
Pubmed: | PMID8161782 PMID 9621519 | ||
CCDS IDs: | CCDSCCDS2679.1 |
Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Products for ACVR2B gene
Catalog | Product Name | Application | Company |
GFS:E06469 | activin A receptor, type IIB; ELISA kit | ELISA | n/a |
GFS:A06469 | activin A receptor, type IIB; Anti | ANTIBODIES | n/a |
GFS:P06469 | activin A receptor, type IIB; Protien | Protien | n/a |