Symbol: Name: ID: |
ACVR1C activin A receptor, type IC GFS:7012 |
Gene name: | ACVR1C |
Chromosome: | 2q24.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ALK7, ACVRLK7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2661081 | Rat Genome Database ID: | RGD:621789 |
HGNC ID: | HGNC:18123 | RefSeq IDs: | NM_001111031 |
Entrez Gene ID: | 130399 | Ensembl Gene ID: | ENSG00000123612 |
VEGA IDs: | OTTHUMG00000131964 | UniProt ID: | Q8NER5 |
UCSC ID: | uc002tzk.3 | OMIM ID: | 608981 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS2205.1 CCDS CCDS46432.1 CCDS CCDS46433.1 CCDS CCDS46434.1 |
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008].
Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Products for ACVR1C gene
Catalog | Product Name | Application | Company |
GFS:E07012 | activin A receptor, type IC; ELISA kit | ELISA | n/a |
GFS:A07012 | activin A receptor, type IC; Anti | ANTIBODIES | n/a |
GFS:P07012 | activin A receptor, type IC; Protien | Protien | n/a |