Symbol: Name: ID: |
ACVR1B activin A receptor, type IB GFS:6287 |
Gene name: | ACVR1B |
Chromosome: | 12q13 |
Previous Symbols: | ACVRLK4 |
Previous Names: | |
Aliases: | ALK4, SKR2, ActRIB |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338944 | Rat Genome Database ID: | RGD:735207 |
HGNC ID: | HGNC:172 | RefSeq IDs: | NM_004302 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000135503 | |
VEGA IDs: | UniProt ID: | P36896 | |
UCSC ID: | uc001rzn.2 | OMIM ID: | 601300 |
Pubmed: | PMID8397373 | ||
CCDS IDs: | CCDSCCDS8816.1 CCDS CCDS44893.1 CCDS CCDS44894.1 |
Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Products for ACVR1B gene
Catalog | Product Name | Application | Company |
GFS:E06287 | activin A receptor, type IB; ELISA kit | ELISA | n/a |
GFS:A06287 | activin A receptor, type IB; Anti | ANTIBODIES | n/a |
GFS:P06287 | activin A receptor, type IB; Protien | Protien | n/a |